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Characteristic neurodegenerative disease neuropathological
lesions involve deposition of abnormal proteins, which can
be intranuclear, cytoplasmic or extracelular. All are labeled
with antibodies (except 15d) as indicated.
(15a) and (15b) HD, intranuclear
inclusion labeled for ubiquitin and huntingtin (cerebral cortex).
(15c) and (15d) AD, neuritic
plaque labeled with Aβ (cerebral cortex) and silver stained.
(15e) and (15f) PD, Lewy
bodies labeled for α-synuclein (fine granular brown
label in this and next panel represent neuromelanin) and phosphorylated
α-synuclein (substantia nigra).
(15g) and (15h) ALS, cyoplasmic
skein of neurofilaments labeled with ubiquitin and with neurofilament
(medulla oblongata).
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