European Iron Club: Metal Based Neurodegenerative Diseases; Figure 12



APP mRNA		FERRITIN - mRNA
APP 5'-UTR sequences were computer-folded to generate the predicted RNA stem loop shown (left RNA secondary structure, Gibbs free energy = 55 kcal/mol) Bold lettering shows the homology with the H-ferritin IRE (right RNA secondary structure)

APP 5' UTR Apex of Stem-loop

IRE

Acute box–Upstream of Start Codon

Figure 12
Evidence for an iron-responsive element
in the 5'-UTR of APP mRNA

CONTENTS
Abstract
1.	Metals in Brain, Metal Transport, Storage and Homeostasis
2.	Oxidative Stress and Redox-Active Metal Ions
3.	Degradation of Cellular Proteins via Proteasomal System
4.	Parkinson's Disease
5.	Alzheimer's Disease
6.	Other Metal-Based Neurodegeneration Diseases
7.	Therapeutic Strategies
References
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