Abstract
This article presents the evidence for metal
based neurodegeneration in certain diseases, e.g. Parkinson
and Alzheimer's Disease. Initially, a marginal increase in
redox active metals leads to the generation of reactive oxygen
species which either damage key proteins, e.g.α-synuclein
or induce pathways leading to abnormal protein production
e.g. βamyloid. Possible therapeutic strategies are presented
which could remove excess metal accumulation or might enhance
levels of the depleted neurotransmitters.
Neurodegeneration, iron, Parkinson's Disease,
Alzheimer's disease
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